Temple University School of Medicine, Biochemistry, 1990.
Professor of Immunology and Microbiology
Associate Director of Research for the Center for Gene Therapy
Tulane University Health Sciences Center.
Email: dphinne@tulane.edu
Dr. Phinney’s research involves examining the basic biology of mesenchymal stem cells (MSCs) using genetic and molecular approaches as well as evaluating in animal models the therapeutic potential of MSCs for treating a variety of disorders. The latter include mouse models of acute and chronic lung injury and mouse and non-human primate models of neurological disorders with a specific emphasis on lysosomal storage diseases.
Crigler, L., Robey, R. C., Asawachaicharn, A., Gaupp, D., Phinney, D. G. Human mesenchymal stem cells express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol. 2006; 198:54-64.
Phinney, D. G., Hill, K., Michelson, C., DuTreil, M., Hughes, C., Humphries, S., Wilkinson, R., Baddoo, M., Bayly E. Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental plasticity and broad clinical efficacy. Stem Cells 2006; 24:186-198.
Isakova, I. A., Baker, K., Dufour, J., Gaupp, D., Phinney, D. G. Pre-Clinical evaluation of adult stem cell engraftment and toxicity in the CNS of Rhesus Macaques. Mol. Therapy 2006; 13:1173-1184.
Phinney, D. G., Baddoo, M., Gaupp, D., DuTreil, M., Isakova, I.A. Murine MSCs transplanted to the CNS of neonatal vs. adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration. Stem Cell Dev. 2006; 15:437-447.
Ortiz, L. A., DuTreil, M., Fattman, C., Pandey, A. C., Torres, G., Go, K., Phinney, D. G. Interleukin 1 receptor antagonist mediates the anti-inflammatory and anti-fibrotic effect of mesenchymal stem cells during lung injury. Proc. Natl. Acad. Sci. USA 2007; 104:11002-11007.
Phinney, D. G. Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle 2007; 6:2884-2889.
Isakova, I. A., Baker, K., Dufour, J., Gaupp, D., Phinney, D. G. Dose and age-related effects on MSCs engraftment levels and anatomical distribution in the CNS of non-human primates: Identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells 2007; 25:3261-3270.
Phinney, D. G. and Prockop, D. J. The state of transdifferentiation and modes of tissue repair: current views. Stem Cells 2007; 25:2896-2902.